And you know what that means – the Geordie duo will be pranking more of their celebrity friends in their segment Undercover, where they dress up in disguises and pull practical jokes on their mates.
So, as the show returns, RadioTimes.com have rounded up some of their best tricks over the years, from simply winding their friends up to setting cars alight…
Simon Cowell meets the worst rappers
We don’t know how they got away with it, but one of the earliest pranks saw Ant & Dec prank their Britain’s Got Talent pal Simon Cowell, as they pretended to audition for American idol in 2013.
Dressed in fake wigs, baggy clothes and fake tatts, the duo rocked up to the audition as brothers Jimmy (Dec) and Scotty (Ant).
As they screamed the lyrics to Paula Abdul’s Opposites Attract, Simon could be seen cringing in his seat before telling them to stop.
But when the boys removed their disguises, he couldn’t believe his eyes as he burst out laughing.
David Dickinson thinks he’s killed someone
The poor antiques expert was left horrified when Dec’s stuntman crashed a car into a ball of flames right on the lawn of his new show Life Treasures, which the duo had created specifically for the prank.
After reuniting Alfie (played by Dec) with his old vehicle that he had previously sold to a salesman (played by Ant), The Duke was in for a shock.
Alfie got into the car and attempted to escape with it after learning the vehicle was now worth £6,500 more.
But it all went wrong when the car flipped over and set on fire, causing David to utter: “Bloody hell.”
Luckily, Ant and Dec decided to put him out of misery as he stood shell shocked staring at the burning car in the distance.
The look on his face was priceless!
Holly Willoughby gets a Surprise Surprise
Holly was left in shock while presenting an episode of Surprise Surprise, where a man’s proposal went wrong.
Played by Ant, Richard attempted to propose to his girlfriend Annabel with the help of boyband Blue. However, it didn’t go down well when Annabel admitted she was in love with her boss (Dec) who was also on the show with her.
As good friends of Holly, Ant and Dec went all out with the prosthetics and make-up.
And they certainly managed to pull the wool over her eyes, as Holly was left terrified when the events unfolded.
One Direction meet their biggest fans – and it goes all wrong
Harry Styles, Niall Horan, Louis Tomlinson, Zayn Malik and Liam Payne were left in stitches when a New Zealand reporter (played by Ant) asked them some very odd questions on a breakfast show.
And things got a lot creepier when the boyband were made to meet their “biggest fans” one of whom was played by Dec and needed medical attention after struggling to breathe in the same room as them.
Piers thinks he’s broken a piece of expensive art
After being the butt of the joke, Simon Cowell decided to get involved this time round as he teamed up with Ant and Dec to trick presenter Piers Morgan.
With Dec posing as an overseas Serbian artist, and Ant dressed up as a gallery security guard, the boys proceeded to pull a fast one on Piers as Simon invited him over to show him his overpriced artwork.
But, when Simon left Piers alone with the painting – which happened to be a black dot on a white canvas – and it went smashing to pieces, Piers looked pretty worried about feeling the wrath of his friend.
And his face said it all when Ant entered the room in disguise and pretended to call the police on him, before revealing his true identity.