The popular character has been battling the illness for months, and girlfriend Peri Lomax (Ruby O'Donnell) has been right by her side, alongside Juliet's big brother James (Gregory Finnegan) and her mum Donna-Marie Quinn (Lucy-Jo Hudson).
Tonight, with Juliet having spent the last few weeks in hospital with norovirus and a kidney infection, which delayed her stem cell transplant, Peri was adamant that Juliet would be coming home that very day. But James urged caution, suggesting that Juliet may not be well enough.
Peri didn't want to hear it and headed to the hospital alone, and she and Juliet spent time "manifesting" happier scenarios. But they were interrupted by a consultant, who asked if they could wait a bit longer as the medical team needed to have a meeting about her treatment and they were still waiting for test results.
Later, the doctors returned to see Juliet and Peri, where they delivered the distressing news that Juliet's kidney levels were still not where they needed to be. The cancer had made her kidney function worse and it had also spread, meaning she would no longer be able to have the transplant or more chemotherapy.
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Juliet zoned out as Peri tried to argue the case, and we saw a vision of Juliet watching herself from outside her hospital room, before she imagined saying future wedding vows to Peri. Numb, Juliet then asked if she could go home. But how will she and Peri, as well as their loved ones, come to terms with what lies ahead?
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Hollyoaks is available to stream on All4 and airs every weeknight at 6:30pm on Channel 4 and 7pm on E4. Check out more of our Soaps coverage or visit our TV Guide and Streaming Guide to see what's on tonight.