The game will air live in the UK on ITV, with coverage starting at 6:30pm.
Who’s in the squads for Uruguay and Portugal?
Goalkeepers: Martin Campana (Independiente), Fernando Muslera (Galatasaray), Martin Silva (Vasco da Gama).
Defenders: Martin Caceres (Lazio), Sebastian Coates (Sporting CP), Jose Maria Gimenez (Atletico Madrid), Diego Godin (Atletico Madrid), Maximiliano Pereira (Porto), Gaston Silva (Independiente), Guillermo Varela (Penarol).
Midfielders: Giorgian De Arrascaeta (Cruzeiro), Rodrigo Bentancur (Juventus), Diego Laxalt (Genoa), Nahitan Nandez (Boca Juniors), Cristian Rodriguez (Penarol), Carlos Sanchez (Monterrey), Lucas Torreira (Sampdoria), Matias Vecino (Inter), Jonathan Urretaviscaya (Monterrey).
Forwards: Edinson Cavani (Paris St-Germain), Maximiliano Gomez (Celta Vigo), Luis Suarez (Barcelona), Cristhian Stuani (Girona).
Goalkeepers: Anthony Lopes (Lyon), Beto (Goztepe), Rui Patricio (Sporting Lisbon).
Defenders: Bruno Alves (Rangers), Cedric Soares (Southampton), Jose Fonte (Dalian Yifang), Mario Rui (Napoli), Pepe (Besiktas), Raphael Guerreiro (Borussia Dortmund), Ricardo Pereira (Porto), Ruben Dias (Benfica).
Midfielders: Adrien Silva (Leicester), Bruno Fernandes (Sporting Lisbon), Joao Mario (West Ham), Joao Moutinho (AS Monaco), Manuel Fernandes (Lokomotiv Moscow), William Carvalho (Sporting).
They will face the winner of France v Argentina, which is played at 3pm on Saturday 30th June.
How did Uruguay and Portugal get to the knockouts?
Uruguay have quietly been having quite a good World Cup. The focus in their group was mainly on what a surprise package Russia proved to be, but Uruguay topped the group with maximum points and without conceding a goal.
After a spectacular opening draw against Spain – thanks to a Cristiano Ronaldo hat trick – Portugal have gone off the boil a bit. Their victory against Morocco was anything but convincing and their bad-tempered draw against Iran cost them top spot in the group.
Who are the players to watch for Uruguay and Portugal?
While it would be easy to pick Uruguay’s strong attacking force of Suarez and Cavani, the efforts of defender Diego Godin will be vital if they’re to progress. The 32-year-old captain is a brick wall at the back and is a huge part of the reason why Uruguay have yet to concede a goal in this World Cup.
For Portugal, you can’t look past the easy pick, Cristiano Ronaldo, who needs no introduction. The World Cup is the one trophy missing from his cabinet and he’ll do anything to win it for his country.
Who’s the top scorer for each team at the World Cup so far?
Uruguay top scorer is striker Luis Suarez with two goals.
To the surprise of no one Portugal’s top scorer is Cristiano Ronaldo with four goals to his name.