Like the first game, High on Life 2 just wouldn't be the same without its stellar cast.

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And while one major name hasn't made the return from the original, that doesn't mean we don't have some big names in the new one.

So, if you're curious who plays who, here's the full High on Life 2 cast and where you may know these voice actors from.

High on Life 2 cast: All voice actors

Here is a list of all the main voice actors in High on Life 2 and their characters:

  • Ralph Ineson – Sheath
  • Richard Kind – Senator Muppy Doo
  • Ken Marino – Travis
  • JB Smoove – Gus
  • Betsy Sodaro – Sweezy

Where do you know the High on Life 2 cast from?

You may not initially know some of these names, but we're sure that you'll recognise some of their other work.

Ralph Ineson – Sheath

Ralph Ineson at "The Fantastic Four: First Steps" World Premiere held at the Dorothy Chandler Pavilion on July 21, 2025 in Los Angeles, California.
Ralph Ineson at The Fantastic Four: First Steps world premiere. Photo by Gilbert Flores/Variety via Getty Images

One of the bigger names on this list, Ralph Ineson is a British acting icon. Now known to many as Galactus in The Fantastic Four: First Steps, he's also been in Nosferatu and Frankenstein on the big screen, as well as Game of Thrones, Chernobyl and The Office UK on TV.

As for his gaming roles, you'll know him as Charles Vane in Assassin's Creed Black Flag, Lorath Nahr in Diablo 4, and Cid in Final Fantasy 16.

Richard Kind – Senator Muppy Doo

Richard Kindattends "All Out: Comedy About Ambition" Gala performance at Nederlander Theatre on December 18, 2025 in New York City.
Richard Kind attends All Out: Comedy About Ambition Gala performance. Photo by Dia Dipasupil/Getty Images

Richard Kind has a stellar acting record in some of the biggest animated films ever, appearing as Bing Bong in Inside Out, Molt in A Bug's Life, Van in Cars and Cars 2, Bookworm in Toy Story 3 and more.

In live action, he's been Max Klein in Argo and Cousin Andy in Curb Your Enthusiasm, among others.

Ken Marino – Travis

Ken Marino at The Variety Studio during the 2026 Sundance Film Festival Presented by Audible at Audible Listening Lodge on January 25, 2026 in Park City, Utah.
Ken Marino at The Variety Studio during the 2026 Sundance Film Festival. Photo by Anna Pocaro/Variety via Getty Images

Ken Marino is a comedic actor who has had some pretty major film roles. He was Victor Pulak in Wet Hot American Summer, Ron Donald in Party Down, and more recently, Larry and Lenny Lehman in Black Monday

JB Smoove – Gus

US comedic actor J. B. Smoove arrives for the 77th Primetime Emmy Awards at the Peacock Theatre at LA Live in Los Angeles on September 14, 2025.
JB Smoove at the 77th Primetime Emmy Awards. Photo by PATRICK T. FALLON/AFP via Getty Images

Returning from the first game, JB Smoove is a stalwart of American comedy. A former SNL writer and performer, he's starred as Leon Black in Curb Your Enthusiasm and Ray in The Millers, among plenty of other shows.

In the gaming world, he's been Bebop in Teenage Mutant Ninja Turtles: Portal Power, and perhaps more famously, Dr. Ray De Angelo Harris in Grand Theft Auto 5.

Betsy Sodaro – Sweezy

Betsy Sodaro as Nancy in Ghosts.
Betsy Sodaro as Nancy in Ghosts. Photo by Bertrand Calmeau/CBS via Getty Images

Another returning actor from High on Life 1, Betsy Sodaro has appeared as Nancy in Ghosts, Bert in Night Court, Dabby in Disjointed Jo Serpent in Puss in Boots: The Last Wish and Chef Ida in The Out-Laws, as well as guest roles on Superstore, Brooklyn Nine-Nine and more.

Sweezy remains her only video game appearance thus far.

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Authors

Gaming writer Alex Raisbeck is sitting down outside, smiling and looking at the camera. He wears a grey hoodie and brown jacket
Alex RaisbeckGaming writer

Alex Raisbeck is a Gaming Writer at Radio Times, covering everything from AAA giants to indie gems. Alex has written for VideoGamer, GamesRadar+, PC Gamer, PCGamesN and more.

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