American medical drama following the tangled lives of interns, residents and their mentors at a fictional Seattle hospital. The title is a reference to Henry Gray's medical textbook Gray's Anatomy and main character Meredith Grey (Ellen Pompeo). It begins with Meredith, Alex (Justin Chambers), George (TR Knight), Izzie (Katherine Heigl) and Cristina (Sandra Oh) as interns in a surgical programme run by chief of surgery Richard Webber (James Pickens Jr). They are initially mentored by general surgeon Miranda Bailey (Chandra Wilson) and work closely with attending neurosurgeon Derek Shepherd (Patrick Dempsey) and cardiothoracic surgeon Preston Burke (Isaiah Washington). "Grey's Anatomy" premiered in 2005. It led to spin-off series "Private Practice".