The biographical movie PT 109 from 1963 highlighted the actions of Kennedy as an officer of the United States Navy during World War II.
http://www.youtube.com/watch?v=gJVYVrh2-Ig Vaughan Meader
The American comedian regular impersonated Kennedy on such programmes as The Ed Sullivan Show. He even recorded a comedy album called The First Family, which was a good-natured parody of Kennedy as both Commander-in-Chief and as a member of a large, well-known political family.
http://www.youtube.com/watch?v=edvdTlAwVd0 Martin Sheen
Starred in the 1983 mini-series Kennedy but had also previously played Robert F Kennedy in the 1974 drama The Missiles of October. Sheen of course went on to star as fictional president Jed Bartlet in The West Wing.
http://www.youtube.com/watch?v=xcmcD8QvQvo Andrew Robinson
The Twilight Zone episode Profile in Silver (1986) featured a history professor from the future being sent back in time to observe the assassination of JFK. Actor Andrew Robinson is perhaps better known for playing the Scorpio Killer in Dirty Harry.
http://www.youtube.com/watch?v=AVRXCA6NRnQ Michael J Shannon
Red Dwarf’s seventh season opener saw Dave Lister (Craig Charles) meeting John F Kennedy in an episode that played with the conspiracies surrounding the killing of the President in 1963.
The CSI star played Kennedy in HBO TV movie The Rat Pack, which depicted Frank Sinatra’s on-and-off friendship with the President.
Took on the role of JFK in docudrama Thirteen Days, Roger Donaldson’s movie from 2000 about the Cuban Missile Crisis of 1962 as seen from the perspective of the US political leadership.
In the movie Watchmen from 2009, the famous Zapruder footage of the assassination in Dallas is recreated with actor Brett Stimely shown taking the bullet.