Grey's Anatomy

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Episode Guide

Series four

Episode 1/17 A Change Is Gonna Come

New residents Meredith, Cristina, Izzie and Alex each have their own group of interns to look after. Among them are Meredith's sparky half-sister Lexie and George, who is forced to repeat a year after failing his exams. It's an eventful first week as casualties pour in following a three-car road accident, and Izzie tries to save the life of a boy's pet deer. Meredith, meanwhile, is preoccupied with her split from Derek.
Episode 2/17 Love/Addiction

George is coming to terms with the fact that he got married for the wrong reasons, and he still loves Izzie and he wants to come clean with his wife. But Izzie senses Callie is under pressure in her new job and persuades him to wait. Lexie can't understand why Meredith is so distant but persists in her attempts to get to know her. Burke's mother arrives at the hospital and demands to see Cristina.
Episode 3/17 Let the Truth Sting

Alex's new intern Norman is old enough to be his father. Together they treat a teenage boy whose behaviour has become so erratic his mother assumes he's on drugs. But when the boy suddenly collapses, Alex discovers that spinal fluid is gathering behind the boy's eye and putting pressure on his brain. Meanwhile, Meredith decides she's had enough of Lexie when a patient dies and Lexie has a hysterical outburst.
Episode 4/17 The Heart of the Matter

Callie has told George that all is forgiven regarding him and Izzie but now she wants to speak to Izzie herself. In a panic, George rushes around trying to find Izzie to warn her, creating the impression among his colleagues that Callie is looking for a confrontation. Meanwhile, Adele has come to the hospital looking for Richard's help with his niece Camille who has a huge tumour in her neck and is refusing treatment.
Episode 5/17 Haunt You Every Day

It's Halloween and Meredith has been dreaming about her mother, so she decides it's time to do something with her ashes - she's just not sure what. In the end, she takes them into work where she finally hits upon a suitable - if unorthodox - resting place. Meanwhile, George has to persuade a patient who needs a heart transplant to allow his daughter to be taken off life support so that he can receive her heart.
Episode 6/17 Kung Fu Fighting

Izzie corners George in the on-call room and demands a night of passion. Meredith struggles with insomnia and wonders whether she can really cope with "break-up" sex with Derek. Alex tries to rebuff Lexie's advances by telling her he can't offer her any commitment. Callie tries to help two injured women who refuse to let go of the wedding dress they are holding.
Episode 7/17 Physical Attraction…Chemical Reaction

It's been a long time coming, but when George and Izzie finally have sex it's an unmitigated disaster, leaving both of them wondering where the chemistry has gone. There are no such problems for Alex and Lexie, although Lexie is very upset by the level of Meredith's hostility to their relationship. Back on the wards, the mother of a newly adopted baby is admitted with a collapsed lung.
Episode 8/17 Forever Young

When a busload of students are brought in after a crash, the hospital staff find themselves reminiscing about their own high-school years. Miranda realises she used to teach the injured driver, and her feelings for him resurface, causing her to become distracted and overlook signs of a heart condition. Meanwhile, Izzie and George tell Meredith about their dismal sex life.
Episode 9/17 Crash into Me (Part 1)

The team must out aside their feelings of distaste when they care for an injured paramedic who refuses treatment from Richard because he is black. Alex invites Ava to sit in on an operation, but Lexie happens to sit next to her in the viewing gallery and is shocked to learn that her neighbour is Alex's girlfriend. Miranda's husband complains that he never sees her now she's the Chief Resident.
Episode 10/17 Crash into Me (Part 2)

Ray, the injured paramedic, wants Meredith to tell his dead colleague's wife that he's sorry he couldn't save him, but Meredith advises him to speak to the widow himself. Izzie agrees to update the family of a patient on the operation he is undergoing, but Erica accuses her of behaving like a social worker. Mark is angry when he realises that Alex has sneaked a friend into the viewing gallery during an operation.