While O'Briain joked on Twitter before the premiere that he might struggle with the debate, as he'd spent part of the day playing a drinking game with Lee Mack for his new stand-up DVD, the Irish comedian had a whale of a time.
"What a mad night," he tweeted, before joking: "The high point was Benedict Cumberbatch telling Stephen exclusive details of the new Star Trek film."
The other panellists evidently enjoyed themselves too, as Adam Rutherford tweeted Athene Donald after the event to say "lovely to meet you at last, sorry we didn't catchup afterwards," to which the Cambridge physicist responded: "Indeed! Hope our paths cross again soon. Interesting event."